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Better Chemistry = Better Drugs
Wull Duh? But in this case it’s a webcast on medchem from some mostly non-chemists: David Snitman, Paul Goddard, Arthur Sands, and Jim Mahoney of Array, ARYx, Lexicon, and Surface Logix respectively....
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XL518
>> update >> An Exelixis Mek application WO/2007/044515 published 4/19/07 So did the IND and deal actually beat the patent application? Either that or I’m missing something, because I...
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XL-518
My guess is XL-518 is in WO/2007/044515. 362 examples, 15 inventors. IND beating first app is unusual. kudos. Wild speculation mode on: The Azetidine 3-hydroxyl residue directly coordinates the Mg...
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WO/2007/96259
Roche has a 2nd gen series of hydantoins as MEK inhibitors with WO/2007/96259: > hydroxamates?
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ARRY-704 ?
aka ARRY-424704 / AZD-8330 is the Array / Astra Mek Ph1 backup to ARRY-886 / AZD-6244 which was put in a holding pattern when it didn’t meet a ph2 endpoint. The pictured strucuture is ‘Mek Inhibitor...
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CH-4987655
Some have walked a country mile to get away from the hydroxamate, others think nothing of tacking ‘nother one on: Its Chugai’s ‘ATP-Collaborative’ Ph1 MEK inhibitor: Ro-4987655 / CH-4987655. More...
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AS-703026
>> Update – this structure has been revised from the butyl amide – This is (i believe) the correct structure >> EMD-Serono’s got ‘a ph1 non-hydroxamate ‘ATP Collaborative’ Mek inhibitor....
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RDEA-119
Its Ardeas’s $35 million non-hydroxamate MEK inhibitor in Ph1. The pictured structure is one of three claimed in the ‘combination w/ Nexavar’ app: WO/2009/018238. “Ardea will grant Bayer a worldwide,...
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RDEA-119
This PDB entry confirms the structure. as always, being 18 months behind the times put you 6 months ahead of the curve. Posted in MEK
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